What is the best calming tablet for dogs?
Zylkene can be used longer term if your pet is very anxious and can also be used in combination with pheromone-based products. Another choice, is Anxitane, a highly palatable, chewable tablet from Virbac that contains the natural ingredient L-Theanine, which helps calm and reduce anxiety in dogs and cats.
Experts agree: an appropriate, high-quality calming supplement can help manage a dog's anxiety, especially if it contains proven calming ingredients like casein, tryptophan, melatonin, and L-Theanine.
- Zesty Paws Stress and Anxiety Calming Bites.
- Virbac Anxitane.
- Vetoquinol Zylkene Behavior Support Capsules.
- Rescue Remedy Pet Drops.
- NaturVet Quiet Moments.
- Licks Little Zen Calming Treats.
- Pet Lab Calming Chews.
- VetriScience Composure Chews.
Diphenhydramine (Benadryl) is an over-the-counter product well-tolerated by dogs and can have a mild sedative effect. Be sure to check with your vet for dosage recommendations.
- Fluoxetine (Prozac®) Fluoxetine is a selective serotonin reuptake inhibitor (SSRI). ...
- Clomipramine (Clomicalm®) Clomipramine is a tricyclic antidepressant (TCA) medication. ...
- Trazodone. ...
- Benzodiazepines (Alprazolam, diazepam) ...
- Gabapentin.
Benadryl Tablets
According to the Merck Veterinary Manual, the standard dose for Benadryl is 2-4 milligrams per kilogram of body weight, or 0.9-1.8 milligrams (mg) of Benadryl per pound. Therefore, a simple and practical dose is 1 mg of Benadryl per pound of your dog's weight, given 2-3 times a day.
Soothing Environment
Some groomers use calming aids in their salons. They'll infuse the space with calming pheromones in the air or essential oils through a diffuser. Perhaps they'll use certain shampoos with soothing ingredients, like lavender.
- Know your breed. ...
- Provide adequate daily exercise. ...
- Teach practical skills. ...
- Give the dog a job. ...
- Don't forget the veterinary check.
Answer: Results may be seen as early as 1-2 days. However, it may take up to 3-4 weeks of daily use to fully notice the benefits of Calm Treats. Question: How long does the effect last? Answer: Every dog is different but generally the effects last about 8-10 hours.
One of the side effects of Benadryl is drowsiness, which helps to calm anxious dogs. The Merck Veterinary Manual states that diphenhydramine may relieve symptoms of mild-to-moderate anxiety in pets associated with travel. It also may help relieve motion sickness.
How do vets calm dogs with anxiety?
Calming collars, pressure wraps, herbal supplements, pheromone sprays, and other anxiety aids can all help make your dog more comfortable at the vet. Medication is also an option, though it's typically considered a last resort. My own anxious dog takes a mild sedative at home a couple hours before each vet visit.
While melatonin has proven beneficial in the management of certain endocrine disorders, it is a helpful adjunct in canine stress disorders. Therefore, melatonin is offered as an over-the-counter recommendation for the dog with hospital associated aggression and anxiety (Table 1).

Benadryl: This mild antihistamine sedative helps keep your pet calm when it is nervous about clipping its nails. Melatonin supplements: Help regulate body rhythm and help calm down your dog. Natural sedation methods: Herbs like California poppy, chamomile, rosemary, or valerian are natural relaxants.
The dog breeds that are more likely to have this problem are the German Shepherd, Australian Shepherd, Border Collie, Jack Russell Terrier, Cavalier King Charles Spaniel, Bichon Frise, Toy Poodle, Labrador Retriever, Cocker Spaniel, and German Shorthaired Pointer.
Veterinarians may recommend melatonin to treat dogs experiencing stress and anxiety, sleeping problems, or certain medical conditions. Melatonin may be suggested in addition to other treatments for these issues because of its potential effects on sleep and behavior.
But anti-anxiety drugs are generally well-tolerated by dogs and can provide much-needed relief and support in certain situations, especially when the separation anxiety is chronic or severe.
If using Benadryl as a mild sedative for motion sickness or any sort of thunderstorm or travel anxiety, it's best to think ahead so you can plan out when you give it to your doggo. It will usually take 30 minutes for Benadryl to take full effect, and you want your pup calm and anxious-free.
Benadryl Dose for Dogs
Plumb's Veterinary Drug Handbook recommends giving a standard dosage of 25 milligrams for a 25-pound dog two to three times per day. As a general rule of thumb, use 1 milligram per pound of your dog's body weight. For example, a 50-pound dog would be given two 25 milligram tablets.
Official answer. The general dose of Benadryl (diphenhydramine) is 2 to 4 mg/kg up to three times day. If your dog weighs 25 lbs (11.3 kg) the dose of Benadryl would be 22.6mg to 45.2mg up to three times a day. Benadryl tablets are available in 25mg and 50mg strength.
According to the American Society for the Prevention of Cruelty to Animals (ASPCA), melatonin is a safe supplement to give to your dog. Melatonin has little risk for harmful side effects . The most common side effect is lethargy upon waking the next morning.
How do you groom a high anxiety dog?
Start with brushing or massaging an anxious dog. Let dogs investigate and sniff tools. Slowly introduce grooming tools; run clippers to get the dog used to the noise before using or use silent clippers that do not make frightening noises. Go slow, be gentle, make sure clippers and blow dryers are not too hot.
Be gentle and firm, but do not yell at or punish a hyper dog as this only increases excitement and makes the behavior worse. Conduct multiple short sessions rather than one long one, if necessary. Brush your dog while she is eating, or provide a chew toy or rawhide bone while grooming.
As with humans, exercise can be a great stress reducer. Physical activities like walking or playing fetch help both you and your dog release tension. It is also good to provide your dog with a safe place in the home where he can escape anxious situations.
It does appear that as dogs age that they become calmer but in fact, your dogs energy level is set at a certain age and will not get less, what will happen though, is that your dog will learn when to be excited and when not to be.
Peanut butter is also great for dogs with anxiety. Many nervous and anxious dogs tend to lick things in order to help them calm down. By using hollow toys like the RuffWear Gnawt-A-Cone, you can put a small amount of peanut butter inside the toy in order to make a long-lasting treat for your dog to lick.
CBD oil can help reduce anxiety in dogs - especially separation anxiety or a noise phobia (think thunderstorms or fireworks). It can also help reduce pain and inflammation - giving a dog suffering from arthritis a better quality of life.
Feeding Directions
25 - 50 lbs: 1 chew daily. 51 - 100 lbs: 2 chews daily. Over 100 lbs: 3 chews daily. Product can be given daily or on an as-needed basis.
You may also notice that Benadryl does, in fact, make your dog sleepy. The majority of side effects occur within the first hour of administration, so monitor your dog's reaction carefully during this time frame. In the event that his reactions are severe, contact your dog's veterinarian immediately.
Dr. Selmer: The most common side effects of Benadryl are lethargy, dry mouth and urine retention. Diarrhea, vomiting and decreased appetite are possible, but not common. There is no evidence that Benadryl will cause fear in dogs.
Sometimes pet parents will give their dogs Benadryl to creatively leverage this side effect—for car travel, during Fourth of July fireworks, or other occasions where the dog needs a mild sedative “to take the edge off.” While sleepiness is a side effect, Benadryl is not actually an effective sleep aid by any means.
How do I know when to medicate my dog for anxiety?
- Sudden unexplained aggression.
- Extreme fear of being left alone that may manifest in the form of destructiveness or escape attempts.
- Constant barking, growling, or whining.
- Obsessive behavior, such as constant licking even when your dog doesn't have fleas or a wound.
- Unexplained fear.
You should give 50 mg of Benadryl to a 50 lb dog, either as two 25 mg tablets, four 12.5 mg chewable tablets, or 20 ml of a Benadryl liquid form (12.5 mg/5 ml).
According to the Merck Veterinary Manual, the safe dosage is 2-4 milligrams of medication per kilogram of weight, or 0.9 to 1.8 milligrams per pound. This amount can be administered two to three times daily, depending on your dog's symptoms.
Dr. Selmer: In dogs, the effects of Benadryl usually last 8 – 12 hours.
Using Over-the-Counter Sedatives
If your veterinarian says it's okay, give your dog 2 mg of Benadryl per 1 kg (2.2 lb) of body weight, or follow your veterinarian's dosing suggestion. Repeat the dose every 4-6 hours while you need to keep your dog sedated.
References
- https://vcahospitals.com/know-your-pet/signs-your-dog-is-stressed-and-how-to-relieve-it
- https://www.mspca.org/angell_services/pre-hospital-sedation-options-for-aggressive-and-anxious-dogs/
- https://www.rover.com/blog/dog-calming-treats-do-they-really-work-a-complete-guide/
- https://wkd-uk.com/dog-training-energy-levels/
- https://www.pethonesty.com/blogs/blog/how-much-benadryl-can-i-give-my-dog
- https://www.drugs.com/medical-answers/how-much-benadryl-can-i-give-my-dog-52673/
- https://rawbistro.com/blogs/raw-bistro/is-cbd-safe-for-dogs
- https://www.kingsdale.com/the-5-best-medications-for-anxious-dogs
- https://www.petnaturals.com/calming-174-30ct.html
- https://sitstay.com/blogs/good-dog-blog/is-peanut-butter-bad-for-dogs
- https://canna-pet.com/articles/side-effects-benadryl-dogs/
- https://www.omnicalculator.com/biology/benadryl-dosage-for-dogs
- https://www.goodtherapy.org/blog/even-dogs-sometimes-need-anxiety-medication-050714
- https://planopaws.com/pages/faqs-for-calm-treats
- https://rufusandcoco.com.au/blogs/blog/10-dog-breeds-prone-to-anxiety-and-how-to-help-them
- https://assisianimalhealth.com/library/medications-and-dog-anxiety/
- https://pets.webmd.com/dogs/can-i-give-my-dog-benadryl
- https://unionlakeveterinaryhospital.com/blog/is-your-pet-anxious-calming-treats-for-dogs
- https://www.airvet.com/blog/can-i-give-my-dog-benadryl/
- https://www.wikihow.com/Safely-Sedate-a-Dog-at-Home
- https://dogsbestlife.com/dog-grooming/nail-clippers/
- https://www.sleepfoundation.org/melatonin/melatonin-for-dogs
- https://www.akc.org/expert-advice/health/benadryl-for-dogs/
- https://www.animeddirect.co.uk/advice/top-calming-products-for-pets/
- https://toegrips.com/benadryl-for-dogs/
- https://www.rover.com/blog/what-can-i-give-dog-for-anxiety/
- https://www.akc.org/expert-advice/training/5-tips-for-a-hyperactive-dog/
- https://iheartdogs.com/giving-benadryl-to-dogs/
- https://www.sleepfoundation.org/animals-and-sleep/can-you-give-dogs-melatonin
- https://www.dtailsgrooming.net/how-groomers-are-able-to-keep-dogs-still/
- https://wagwalking.com/grooming/groom-a-dog-with-anxiety
- https://wagwalking.com/grooming/groom-a-hyper-dog
- https://www.petmd.com/dog/care/can-i-give-my-dog-benadryl-and-if-so-how-much
- https://www.rover.com/blog/taking-an-anxious-dog-to-the-vet/